The Los Angeles Chargers will try to avoid being eliminated from playoff contention when they host the Buffalo Bills in a Week 16 NFL game on Saturday at SoFi Stadium. After losing five of its last six games, Los Angeles (5-9) has sunk to the bottom of the NFC West standings, prompting the firing of head coach Brandon Staley last week. The Chargers would be eliminated from postseason contention with a loss on Sunday. Even if they win, they would be eliminated by a Jaguars victory or by a combination of other teams winning in Week 16. Meanwhile, the Bills (8-6) are in a dogfight for one of the three wild card spots in the AFC.
Kickoff is scheduled for 8 p.m. ET. Buffalo is a 12-point favorite in the latest Bills vs. Chargers odds while the over/under for total points scored is 44.5. Before you make any Chargers vs. Bills picks or NFL predictions, you need to see the NFL betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has zeroed in on Bills vs. Chargers and identified its picks and predictions. You can see the model’s picks only at SportsLine. Here are several NFL odds and betting lines for Chargers vs. Bills:
- Bills vs. Chargers spread: Buffalo -12
- Bills vs. Chargers over/under: 44.5 points
- Bills vs. Chargers money line: Buffalo -772, Los Angeles +529
- BUF: James Cook ranks second in the league in rushing yards (968)
- LAC: Khalil Mack is tied for second in forced fumbles (five)
- Bills vs. Chargers: See picks here
Why the Bills can cover
Buffalo’s James Cook has been one of the best running backs in the league this season. The second-year back from Georgia ranks second in the NFL in rushing yards (968), behind only Christian McCaffrey. Cook is coming off his best-ever game, rushing for a career-high 179 yards and one touchdown in the 31-10 blowout of the Cowboys.
Cook and the rest of the offense will face a Los Angeles defense that has struggled all season. The Chargers give up 375.3 total yards per game this year; just three teams allow more. They also concede 5.6 yards per play, which ranks 27th in the league. See which team to pick here.
Why the Chargers can cover
Los Angeles has dominated the head-to-head series against Buffalo recently. The Chargers have won four of the last five meetings against the Bills played anywhere and 11 of the last 13, including the last six straight, played at home. Buffalo hasn’t won on the road against the Chargers since 1981
In addition, Los Angeles is catching a potentially vulnerable Bills team on Saturday. Buffalo is coming off a three-game gauntlet with games against the Eagles, Chiefs and Cowboys. The Bills wouldn’t be the first team to not be completely focused mentally after a three-game stretch like that. See which team to pick here.
How to make Bills vs. Chargers picks
SportsLine’s model is leaning Under the point total, predicting 43 total points. The model also says one side of the spread cashes in more than 50% of simulations. You can see the model’s NFL picks and analysis only at SportsLine.
So who wins Chargers vs. Bills on Saturday, and which side of the spread cashes in more than 50% of simulations? Visit SportsLine now to see which side of the Bills vs. Chargers spread you should jump on, all from the advanced model on a 178-129 roll on NFL picks, and find out.
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Author: CBS Sports Staff
December 23, 2023 | 1:10 pm
