Giants vs. Bills odds, spread, line: Sunday Night Football picks, NFL predictions by expert on 42-22 run

Josh Allen and the Buffalo Bills aim to bounce back with a victory over the New York Giants on Sunday Night Football. The Bills suffered a 25-20 loss to the Jacksonville Jaguars in London a week ago, falling to 3-2 this season. Buffalo is unbeaten at home, however, and the Bills will face a New York team that will be without its starting quarterback. Giants QB Daniel Jones has been ruled out of Sunday’s contest with a neck injury. The Giants are 1-4 overall and 1-2 on the road, including a loss to Miami a week ago.

Kickoff is at 8:20 p.m. ET in Buffalo. The Bills are 15-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 43.5 in the latest Giants vs. Bills odds from the SportsLine consensus. Before you make any Bills vs. Giants picks and NFL predictions, you need to see what SportsLine expert R.J. White has to say, considering his mastery of picks involving New York.

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and went 535-450-30 on his ATS NFL picks from 2017-22, which returned more than $3,500 to $100 players. He also closed the 2022 NFL season on an incredible 107-80-6 run on his last 193 against-the-spread and total NFL picks, returning more than $1,800 for $100 bettors. Moreover, White has a read on the pulse of the Giants. He is an amazing 42-22 on his last 64 picks involving New York. Anyone who has followed him is way up.

Now, White has set his sights on Giants vs. Bills and just locked in his picks and NFL predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and betting lines for Giants vs. Bills:

• Giants vs. Bills spread: Bills -15
• Giants vs. Bills over/under: 43.5 points
• Giants vs. Bills money line: Bills -1291, Giants +775
• NYG: Giants are 0-5 against the spread this season
• BUFF: Bills are 3-2 against the spread this season
• Giants vs. Bills Picks: See picks at SportsLine
• Giants vs Bills live stream: fubo (try for free)

Why the Giants can cover

Buffalo’s offense is tremendous this season, but the team did struggle to only 29 rushing yards in the Week 5 loss to Jacksonville. New York has allowed only six passing touchdowns in five games, and there are also avenues for positivity from the Giants against Buffalo’s defense. The Bills allowed nearly 500 yards of offense in losing to Jacksonville in London, and Buffalo is now shorthanded following the loss of first-team All-Pro linebacker Matt Milano to injury. 

The Bills are struggling badly against the run, giving up 5.8 yards per carry and more than 130 yards per game, and New York will have a dual-threat quarterback on the field with Tyrod Taylor under center. Buffalo is also giving up 5.7 yards per play, No. 26 in the NFL, and the Giants have a real weapon in Darren Waller at tight end. Waller caught eight passes for 86 yards a week ago, and he is averaging 63.7 receiving yards per game over the last five seasons, ranking near the top of the league among tight ends. See which team to pick here.

Why the Bills can cover

Josh Allen and Stefon Diggs lead an elite Buffalo offense that can keep constant pressure on New York. Allen is leading the NFL with a 73.1% completion rate this season, and he ranks in the top five of the league in passing yards, total offense, passing touchdowns, passer rating, and QBR. In the last 10 home games, Allen is averaging more than 275 passing yards per game with 27 touchdowns and six interceptions, and he is 9-1 in those outings. Allen’s top target is Diggs, who entered 2023 with five straight 1,000-yard seasons. He ranked in the top five of the NFL in receptions and receiving yards in 2022, and Diggs is one of only three players in the league with at least 500 receiving yards and five receiving touchdowns through five weeks. 

With Allen and Diggs at the forefront, the Bills are averaging 31.8 points per game and scoring on half of offensive possessions. Buffalo is in the top four of the NFL in total yards per game, yards per play, red zone efficiency, and third-down efficiency, and the Bills are dynamic and versatile on that side of the ball. The Bills are also facing a New York defense that is giving up 30.6 points per game and 378.0 total yards per contest, with the fewest sacks (five) in the NFL this season. See which team to pick here.

How to make Giants vs. Bills picks

White has analyzed this matchup and while we can tell you he’s leaning Over the point total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

Who wins Bills vs. Giants on Sunday Night Football, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Bills vs. Giants spread to back, all from the expert on a 42-22 roll on picks involving New York, and find out.