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2024 Week 16 NFL score predictions, game picks, odds: Model says exact scores from 10,000 simulations

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Aaron Rodgers and the New York Jets snapped a four-game losing streak with a 32-25 victory over the Jacksonville Jaguars last week. Rodgers looked like his vintage self in the win, throwing for 289 yards and three touchdowns. He also led the team in rushing with six carries for 45 yards. On Sunday, Rodgers and the Jets will host Matthew Stafford and the Los Angeles Rams, who currently sit atop the NFC West standings with an 8-6 record. According to the latest Week 16 NFL odds, the Jets are three-point underdogs at home with an over-under of 46.5, up a half-point from the opening line. New York is a +136 underdog on the money line (risk $100 to win $136).

Should your Week 16 NFL picks include backing the Jets to cover the spread, or are you better off targeting other Week 16 NFL underdogs like the Commanders (+4, 46.5) at home against the Eagles or the Vikings (-3, 42.5) against the Seahawks? Making NFL score predictions on all 16 Week 16 games can help form not only Week 16 NFL spread picks, but also NFL over/under picks, NFL parlays, and even Week 16 NFL survivor strategy. Which Week 16 NFL games will be lopsided, and which ones will play out closer to their NFL spreads? Before you make any Week 16 NFL picks, make sure you see what SportsLine’s advanced computer model has to say

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2024 NFL season on an incredible 27-11 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 207-139 roll on top-rated NFL picks that dates back to the 2017 season and a 61-32 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns at their best sports betting app.

Now, the model has simulated every Week 16 game 10,000 times. You can only see the model’s Week 16 NFL exact score predictions at SportsLine.

Top Week 16 NFL picks

After diving into every game on the Week 16 NFL schedule, the model is backing the Tampa Bay Buccaneers (-4, 48) to beat the Dallas Cowboys, 28-22, on Sunday Night Football. The Buccaneers will enter Sunday’s showdown full of confidence after securing a dominant 40-17 victory on the road against the Los Angeles Chargers last week. Tampa Bay is now 8-1 in its previous nine games played in December. 

Tampa Bay features one of the league’s most explosive offenses, averaging 388.3 yards per game, which ranks third in the NFL. Quarterback Baker Mayfield was effective in last week’s win over Los Angeles, throwing for 288 yards and four touchdowns. Mayfield ranks third in the NFL with 32 touchdown passes this season. 

The Cowboys, meanwhile, are giving up 27.1 points per game, which ranks 29th in the league. In addition, Dallas is 1-8 against the spread in its last nine games at home. The model projects Mayfield will throw for 283 yards and two touchdowns, while Tampa Bay’s defense racks up 2.5 sacks on average. See the model’s other Week 16 NFL score predictions at SportsLine

How to make Week 16 NFL score predictions

In addition, the model has locked in exact score predictions for this week’s biggest matchups including Eagles vs. Commanders, Vikings vs. Seahawks and 49ers vs. Dolphins. It’s also calling for multiple underdogs to pull off shocking upsets. Nailing these results is key to making profitable Week 16 NFL picks. You can only see them at SportsLine

Who wins each Week 16 NFL game, and which underdogs pull off shocking upsets? Visit SportsLine now to get the model’s NFL Week 16 score predictions, all from the model on a 207-139 roll on top-rated NFL picks, and find out. 

Where to bet on NFL games

Here are the top sportsbooks to bet on NFL games this week, along with the various NFL sportsbook promos they currently offer.

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Author: CBS Sports Staff
December 22, 2024 | 10:40 am

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