2024 Week 12 NFL picks, odds, best bets from advanced model: This 5-way football parlay pays 25-1

The Kansas City Chiefs will try to bounce back from a loss for the first time since 2023 when they face the Carolina Panthers on Sunday during the Week 12 NFL schedule. Kansas City had its 15-game winning streak and bid for a perfect season spoiled in a 30-21 loss to Buffalo in an AFC showdown last week. The Chiefs are 11-point road favorites at Carolina in the Week 12 NFL odds, with an over-under of 43, despite the Panthers entering with an extra week of a rest and a two-game winning streak. Should you back the Panthers as double-digit underdogs with your Week 12 NFL parlay picks and NFL best bets?

Washington is also a double-digit favorite this week, listed at -10.5 against Dallas in the Week 12 NFL Vegas odds, with an over-under of 45. The Commanders are on a two-game losing streak and were swept by the Cowboys last season, so there could be an argument to fade Washington with your Week 12 NFL predictions. The Cowboys will once again be without quarterback Dak Prescott, who is out for the year with a hamstring injury. Before you make any Week 12 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 12 of the 2024 NFL season on an incredible 20-8 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 200-136 roll on top-rated NFL picks that dates back to the 2017 season and a 54-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has scoured the Week 12 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 12 NFL picks at SportsLine.

Top Week 12 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-7.5, 50.5) to cover against the Indianapolis Colts. Detroit was the heaviest favorite of any team in the league this season when it closed as a 13.5-point favorite against Jacksonville last week, but the Lions had no problem covering that number in a 52-6 win. Their 46-point winning margin was the largest in franchise history, and their 645 total yards were also a franchise record. 

They have won eight straight games and nine of their first 10 games, becoming the third team in the Super Bowl era to win three of their first 10 games by at least 35 points. Detroit’s offense is averaging a whopping 33.6 points per game, which is going to cause problems for an Indianapolis offense that is scoring just 21.5 points per game. The Lions have covered the spread in seven of their last eight games, and the model has them covering in well over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 12 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s Week 12 NFL best bets and NFL parlay at SportsLine.

What are the model’s top Week 12 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 12 NFL best bets from a model on an 200-136 run on top-rated picks, and find out.