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NFL DFS, Thursday Night Football picks: Best 49ers vs. Seahawks fantasy lineup advice for FanDuel, DraftKings

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49ers quarterback Brock Purdy is averaging 281.5 passing yards over four games against Seattle ahead of 49ers vs. Seahawks on Thursday Night Football, so should daily Fantasy football players include him in their NFL DFS lineups? If so, which of the bevy of 49ers playmakers like Deebo Samuel, Brandon Aiyuk or George Kittle from the NFL DFS player pool should you include in your NFL DFS picks? The Seahawks are averaging 12.3 points in four regular-season games over the last two seasons against the 49ers, but with talented weapons such as DK Metcalf, Kenneth Walker and Tyler Lockett, who should you include in NFL DFS lineups? Before locking in any NFL DFS lineups for Seahawks vs. 49ers on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who cashed big all season in 2022, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks on sites like DraftKings and FanDuel.

Kaylor hit on epic NFL DFS picks for SportsLine members throughout the 2022 and 2023 seasons. In 2022, he was all over Travis Kelce’s four-touchdown performance against the Raiders on Monday Night Football, Kirk Cousins‘ 460-yard, four-TD performance on Thanksgiving Day, and T.J. Hockenson’s 13 catches for 109 yards and two touchdowns in Week 15. In 2023, he hit on Ja’Marr Chase’s massive Week 5 performance (15 catches, 192 yards, three TDs), D.J. Moore’s eight catches for 230 yards and three touchdowns in Week 14, and De’Von Anchane’s breakout performance (233 total yards, four TD’s) in Week 3. Anyone who followed his picks is way up.

This season, in the Sao Paulo game one of Kaylor’s top picks was Green Bay wide receiver Jayden Reed, who caught four passes for 138 yards and a touchdown and rushed for 33 yards and a score, and James Cook, who scored three touchdowns on Thursday Night Football against the Dolphins

Now, Kaylor has turned his attention to 49ers vs. Seahawks on Thursday Night Football in Week 6 and locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Seahawks vs. 49ers

One of Kaylor’s top NFL DFS picks for Thursday Night Football is 49ers running back Jordan Mason, who rushed for 89 yards on 6.4 yards per carry last week against the Cardinals. He’s averaged at least 5.0 yards per carry in four of five games this season as he’s taken the opportunity to become the 49ers starting running back and left no doubt that he’s the worthy next-man up with McCaffrey (Achilles/calf) injured. The coaching staff has shown confidence in Mason since Week 1 despite the 25-year-old being an undrafted player who only had 83 carries over his first two seasons.

Mason rushed for 147 yards on 28 carries with a touchdown in Week 1 against the Jets on Monday Night Football after McCaffrey was ruled out shortly before kickoff. He’s rushed for at least 100 yards in three of five games this season and the Seahawks are allowing 128 rushing yards per contest, which ranks 20th in the NFL. The Seahawks are allowing the eight-most rushing yards to running backs in the NFL season, which makes this a strong matchup for Kaylor in forming Thursday Night Football NFL DFS lineups. 

Kaylor is also targeting Seahawks wide receiver Jaxon Smith-Njigba, who had his first touchdown of the season last week and has 19 targets over his last two games. The second-year receiver has become a more significant piece of the Seattle offense this season, averaging eight targets per game compared to 5.5 targets per contest last season.

The Seahawks selected Smith-Njigba with the No. 20 overall pick in the 2023 NFL Draft as the first receiver off the board. That was largely due to his breakout sophomore season when he led the Big Ten in receptions (95) and receiving yards (1,606). A hamstring injury derailed his final college season but he’s shown his big-play ability at the NFL already. He has at least one catch of 15 yards or more in three of five games this season and given the 49ers are sure to focus much of their defensive attention on containing Metcalf, Smith-Njigba could be in line to be a significant value at his price for NFL DFS lineups. See who else Kaylor likes right here.

How to set 49ers vs. Seahawks NFL DFS lineups, player pool

Kaylor is also targeting another undervalued player who could explode for huge numbers in Seahawks vs. 49ers. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor’s NFL DFS picks, at SportsLine.

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Thursday Night Football, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who won a prestigious millionaire maker tournament, and find out.

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Author: CBS Sports Staff
October 9, 2024 | 10:01 am

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