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2024 Week 1 NFL picks, odds, best bets from advanced model: This 5-way football parlay would pay out 25-1

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Of the Week 1 NFL lines, Giants vs. Vikings has move the most since when sportsbooks first set the number. New York opened as 1-point home favorites, but there has been a 2-point shift, and now Minnesota is favored by one in the latest Week 1 NFL odds. The betting public pouring money in on the Vikings could make the team one to back as part of your Week 1 NFL parlay picks. However, the public is often wrong, and there’s a reason why the city of Las Vegas has so many fancy hotels and casinos since it’s usually on the winning end of bets. You can pick and choose which Week 1 NFL bets to include in an opening-week NFL parlay, and Vikings vs. Giants may be one to avoid entirely. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine.

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-3.5) to cover at home against the Los Angeles Rams. This game takes place on Sunday Night Football, and the Lions have a habit of taking care of business when the lights are brightest. They are 6-0 against the spread in primetime games since 2022. Additionally, Detroit went 14-6 ATS overall counting both the regular season and postseason in 2023. Those 14 victories were the most in the NFL, as was its 70% cover rate.

Detroit defeated the Rams in last year’s Wild Card Round, and since then, L.A. has had a plethora of losses on the defensive side. Its best player in Aaron Donald retired, plus the team lost its leading tackler, Ernest Jones, and the two players who tied for the team lead in interceptions — Jordan Fuller and Ahkello Witherspoon. With the Rams also losing four of their last five road games versus the Lions, the model comfortably backs Detroit (-3.5) to cover almost 60% of the time. See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home favorite that covers the spread in almost 70% of simulations. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine

What are the model’s top Week 1 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 185-129 run on top-rated picks, and find out.

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Author: CBS Sports Staff
September 4, 2024 | 8:31 pm

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