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2024 Week 1 NFL picks, odds, best bets from advanced model: This five-way football parlay would pay out 25-1

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The preseason is over, which means fans and bettors are turning their attention to the 2024 NFL regular season. Two-time defending champion Kansas City opens the season against Baltimore in a rematch of last season’s AFC Championship, when the Chiefs picked up a win in a low-scoring affair. They are 3-point home favorites in the Week 1 NFL odds, but Baltimore will be motivated to avenge last year’s loss. The Chiefs were upset by the Lions in last season’s NFL Kickoff Game, so should you fade Kansas City with your Week 1 NFL parlay picks?

There are thrilling NFL matchups throughout the Week 1 NFL schedule, which concludes on Monday Night Football when the 49ers host the Jets. New York has quarterback Aaron Rodgers back from a season-ending injury, but San Francisco is a 3.5-point favorite in the Week 1 NFL spreads. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine.

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-3.5) to cover at home against the Los Angeles Rams. The Lions enter the season with the fourth-best Super Bowl odds following their trip to the NFC Championship game last season. They beat the Rams in a 24-23 final during the wild-card round, and they should be even better to open the 2024 campaign.

Quarterback Jared Goff leads a loaded offense that includes wide receiver Amon-Ra St. Brown and tight end Sam LaPorta, along with a two-headed running back duo of David Montgomery and Jahmyr Gibbs. They are facing a Rams defense that lost future Hall of Famer Aaron Donald to retirement in the offseason, which will make it even more difficult for them to slow down Detroit. SportsLine’s model has Detroit scoring more than 30 points in this game, helping the Lions cover the spread in almost 60% of the latest simulations.Β See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home favorite that covers the spread in almost 70% of simulations.Β You can only see the model’s NFL Week 1 best bets and parlay at SportsLine.Β 

What are the model’s top Week 1 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 185-129 run on top-rated picks, and find out.

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Author: CBS Sports Staff
September 3, 2024 | 10:16 am

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