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2024 Week 1 NFL picks, odds, best bets from proven model: This five-way football parlay pays out 25-1

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Following a rough stint with the Broncos, veteran quarterback Russell Wilson will look for a fresh start with the Steelers. Pittsburgh opens the 2024 NFL schedule with a game against the Falcons. The Steelers are 15-2-1 in their last 18 games against the Falcons, but Atlanta is a three-point home favorite in the Week 1 NFL odds. Both offenses are debuting new quarterbacks, as the Falcons signed Kirk Cousins in the offseason, upending the NFL odds. Other teams like the Bears (Caleb Williams) and Commanders (Jayden Daniels) will have rookie quarterbacks starting in Week 1.

Evaluating those offenses can be difficult compared to teams with returning quarterbacks, so how should you approach them with your Week 1 NFL parlay picks on the latest NFL betting lines? Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 185-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 39-21 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine.

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Detroit Lions (-3.5) to cover at home against the Los Angeles Rams. Detroit has been the best team in the league to back over the past three seasons, covering the spread at a 37-17 clip since 2021. The Lions were favored in 16 of their 20 total games last year, but they were still able to cover the number in six of their final seven games.

They have one of the most complete rosters in the NFL, retaining almost all of their weapons from a team that played in the NFC Championship last season. Quarterback Jared Goff has ranked inside the top 10 in the last two years with 59 total touchdowns, while running back Jahmyr Gibbs and tight end Sam LaPorta scored 21 combined touchdowns as rookies. They should take another step forward as second-year players, which is one reason why the model has Detroit covering the spread in well over 50% of the latest simulations. See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home favorite that covers the spread in almost 70% of simulations. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine

What are the model’s top Week 1 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 185-129 run on top-rated picks, and find out.

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Author: CBS Sports Staff
August 27, 2024 | 3:05 pm

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