Week 16 NFL picks, odds, 2023 best bets from proven model: This 5-way football parlay pays 25-1

A pair of Super Bowl contenders will meet during the Week 16 NFL schedule when San Francisco hosts Baltimore on Monday Night Football. The Ravens have won eight of their last nine games, while the 49ers are riding a six-game winning streak following their 45-29 victory at Arizona last week. San Francisco is a 5.5-point favorite in the Week 16 NFL odds from the SportsLine consensus. Should you include either of those teams in your Week 16 NFL parlay picks?

Another game with playoff implications features Tampa Bay vs. Jacksonville on Sunday. The Buccaneers have won three straight games to take over first place in the NFC South, but should they be a team you target with your Week 16 NFL bets? Before you make any Week 16 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2023 NFL season on an incredible 178-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 32-21 roll on top-rated NFL picks since Week 7 of last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 16. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 16 NFL picks at SportsLine.

Top Week 16 NFL picks

After simulating every game 10,000 times, the model is high on the New York Jets (-3) to cover against the Washington Commanders. Washington has been one of the worst teams in the NFL since the beginning of November, suffering five straight losses. The Commanders fell to the Rams in a 28-20 final last week, failing to cover the spread as 6.5-point road underdogs. 

They will be on the road for the third time in a four-game stretch this week, and New York cruised to a 30-6 win over Houston in its most recent home game. Second-year wide receiver Garrett Wilson caught nine passes for 108 yards in that game, while running back Breece Hall accounted for more than 120 total yards. SportsLine’s model expects Hall to come close to another 100-yard performance on Sunday, which is one reason why the Jets are covering the spread in well over 50% of the latest simulations. See which other NFL parlay picks to make here.

How to make Week 16 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s Week 16 NFL best bets and parlay at SportsLine. 

What are the model’s top Week 16 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 16 NFL best bets from a model on a 178-129 run on top-rated picks, and find out.