Bills vs. Giants prediction, odds, line, spread, time: Sunday Night Football picks by model on 171-119 roll

The Buffalo Bills (3-2) will host the New York Giants (1-4) in a primetime battle on Sunday Night Football. The Bills are looking to bounce back after having their three-game win streak halted last week in London, where the Jaguars beat Buffalo, 25-20. New York has lost three games in a row. In Week 5, the Giants fell to the Miami Dolphins, 31-16. The Giants have failed to cover in a game this season, while the Bills are 3-2 against the spread. Quarterback Daniel Jones (neck) is out for New York.

Kickoff from Highmark Stadium in Orchard Park, N.Y. is set for 8:20 p.m. ET. The Bills are 15-point favorites in Bills vs. Giants odds, while the over/under for total points scored is 44. Before making any Giants vs. Bills picks, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer simulation model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2023 NFL season on an incredible 171-119 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 25-11 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Giants vs. Bills and just revealed its picks and predictions. You can visit SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Giants vs. Bills:

• Bills vs. Giants spread: Buffalo -15
• Bills vs. Giants Over/Under: 44 points 
• Bills vs. Giants money line: Buffalo -1270, New York +767
• NYG: Under is 5-1 in the Giants’ last six games
• BUF: Buffalo has gone over the total twice in three home games this year
• Bills vs. Giants picks: See picks at SportsLine
• Bills vs. Giants live stream: fubo (try for free)

Why Bills can cover

Buffalo’s offense has several effective playmakers. Running back James Cook owns strong athleticism in both phases of the game. Cook has solid patience as a runner with secure hands coming out of the backfield. The Georgia product has 292 rushing yards, 140 receiving yards, and one touchdown. In Week 3 versus the Commanders, Cook finished with 112 scrimmage yards.

Receiver Gabe Davis uses his 6-foot-2 frame to win downfield. Davis attacks jump balls and knows how to create separation. The UCF product has snagged 18 receptions for 320 yards and four touchdowns. Additionally, Davis leads the team with six catches of 20-plus yards. In the loss to the Jaguars, the 24-year-old logged six receptions for 100 yards and one score. See which team to pick here.

Why Giants can cover

New York has an alert and instinctive playmaker in the middle of the field. Linebacker Bobby Okereke is a high-energy player with terrific angles in pursuit. Okereke currently leads the team in total tackles (42) with three tackles for loss and three pass deflections. He has also notched double-digit stops in back-to-back games. Last week versus Miami, the Stanford product had 10 total tackles and one interception.

The duo of Jason Pinnock and Xavier McKinney have been strong at safety. Pinnock can flip his hips easily in coverage and has plenty of range. The Pittsburgh product is third on the team in total tackles (30) with three tackles for loss and one interception. McKinney has strong play-recognition skills and tackles well. The Alabama product has secured 29 total tackles and four pass breakups. See which team to pick here.

How to make Giants vs. Bills picks

SportsLine’s model is leaning over the point total, projecting the teams to combine for 51 points. The model also says one side of the spread hits in well over 50% of simulations. You can only set the model’s pick at SportsLine.

So who wins Giants vs. Bills on Sunday Night Football, and which side of the spread hits in well over 50% of simulations? Visit SportsLine now to see which side of the Giants vs. Bills spread you should jump on, all from the advanced model that is up more than $7,000 on top-rated NFL picks, and find out.